Genotype Probabilities at Intermediate Generations in the Construction of Recombinant Inbred Lines

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Genotype Probabilities at Intermediate Generations in the Construction of Recombinant Inbred Lines

The mouse Collaborative Cross (CC) is a panel of eight-way recombinant inbred lines: eight diverse parental strains are intermated, followed by repeated sibling mating, many times in parallel, to create a new set of inbred lines whose genomes are random mosaics of the genomes of the original eight strains. Many generations are required to reach inbreeding, and so a number of investigators have ...

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The genomes of recombinant inbred lines.

Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relati...

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ژورنال

عنوان ژورنال: Genetics

سال: 2012

ISSN: 1943-2631

DOI: 10.1534/genetics.111.132647